gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred CMV-specific CTLs recognize CMV pp65 peptide–HLA I via their native TCR and kill target cells by releasing cytotoxic granules (perforin/granzymes) leading to apoptosis (and possibly Fas/FasL signaling).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–HLA class I complex on CMV-infected cells; allele-restricted (e.g., HLA-A/B/C)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05564598
disease_id_num_tar_ref
4158
drug_id_num_tar_ref
11229