gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds Nectin-4, is internalized, and releases MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptotic death (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC cell-surface antigen; binding triggers internalization and MMAE release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06592326
disease_id_num_tar_ref
4250
drug_id_num_tar_ref
11483