gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This ADC binds Nectin-4 on tumor cells, is internalized, and releases MMAE; MMAE inhibits beta-tubulin polymerization, causing G2/M arrest and apoptosis. Beta-tubulin expression alone does not render cells directly targeted by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit tubulin polymerization (microtubule disruption)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06592326
disease_id_num_tar_ref
4250
drug_id_num_tar_ref
11483