gene_symbol
MAGEA1
hgnc_id
HGNC:6796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic cells present HLA-A2–restricted MAGE-1 peptides to T cells, inducing MAGE-1–specific CD8+ CTLs that recognize MAGE-1 peptide–HLA complexes on tumor cells and kill them via perforin/granzyme-mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A2–restricted peptide epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT02546102
disease_id_num_tar_ref
4274
drug_id_num_tar_ref
11556