gene_symbol
PMEL
hgnc_id
HGNC:10880
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic cell vaccine presents gp100 peptide to T cells, priming gp100-specific CD8+ CTLs that recognize HLA-A2–presented gp100 epitopes on tumor cells and kill them via perforin/granzyme-mediated cytolysis (and Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A2–restricted peptide epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT02546102
disease_id_num_tar_ref
4274
drug_id_num_tar_ref
11556