gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes HER2-peptide–specific CD8+ T cells; these CTLs recognize HER2-derived epitopes on HLA-A2 on tumor cells and kill them via perforin/granzyme-mediated cytolysis (and related apoptotic pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A2–restricted peptide epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT02546102
disease_id_num_tar_ref
4274
drug_id_num_tar_ref
11556