gene_symbol
IL13RA2
hgnc_id
HGNC:5975
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine’s dendritic cells prime IL-13Rα2-specific CD8+ T cells (HLA-A2–restricted), which recognize IL-13Rα2 peptides on tumor MHC I and kill target cells via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A2–restricted peptide epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT02546102
disease_id_num_tar_ref
4274
drug_id_num_tar_ref
11556