gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on target cells and, upon CD28/CD3zeta signaling, directly kill them via perforin/granzyme-mediated cytolysis and Fas-FasL apoptosis; IL-18 secretion enhances T/NK activation and persistence.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-lineage membrane antigen on leukemic B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287528
disease_id_num_tar_ref
4287
drug_id_num_tar_ref
11603