gene_symbol
IL18R1
hgnc_id
HGNC:5988
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL18R1-expressing cells are not targeted for killing. The CAR T cells kill CD19+ cells via CAR-triggered cytotoxicity (perforin/granzyme, FasL), while secreted IL-18 binds IL18R1 on immune cells to enhance their activity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary (alpha) subunit of the IL-18 receptor; forms signaling complex with IL18RAP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287528
disease_id_num_tar_ref
4287
drug_id_num_tar_ref
11603