gene_symbol
IL18RAP
hgnc_id
HGNC:5989
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CAR targets CD19, not IL18RAP; secreted IL-18 engages IL18RAP to activate immune cells and modulate the microenvironment, but does not directly kill IL18RAP-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Accessory (beta) subunit of the IL-18 receptor; required for signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287528
disease_id_num_tar_ref
4287
drug_id_num_tar_ref
11603