gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind GPC3 via the CAR and directly kill target cells through perforin/granzyme-mediated apoptosis (and Fas/FasL).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface heparan sulfate proteoglycan overexpressed on hepatocellular carcinoma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06641453
disease_id_num_tar_ref
374
drug_id_num_tar_ref
1054