gene_symbol
DKK1
hgnc_id
HGNC:2891
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes DKK1-specific cytotoxic T cells that recognize DKK1 peptides on MHC and kill DKK1-expressing cells via CTL mechanisms (perforin/granzyme, Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen; presented as DKK1 peptide epitopes on autologous dendritic cells via MHC I/II to prime T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT03591614
disease_id_num_tar_ref
4346
drug_id_num_tar_ref
11776