gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The CD70-targeted ADC binds CD70 on CD70+ cells, is internalized, and releases a topoisomerase I inhibitor that induces DNA damage, leading to apoptosis of the target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface antigen (TNF ligand family); ADC binding target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05721222
disease_id_num_tar_ref
4454
drug_id_num_tar_ref
12039