gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ARX788 binds HER2 on tumor cells and is internalized; lysosomal release of an MMAF analog then binds the Vinca site on beta-tubulin, inhibiting microtubule polymerization and causing G2/M arrest and apoptosis in HER2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Auristatin/MMAF analog (opadotin) binds the Vinca domain to inhibit tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06578286
disease_id_num_tar_ref
4470
drug_id_num_tar_ref
12079