gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ALETA-001 binds the anti-CD19 CAR on infused CAR T cells and antigens on malignant B cells, bridging them to form an immune synapse that activates/expands CAR T cells, which then kill B-cell tumors via T-cell cytotoxicity (perforin/granzyme). The CAR T cells (the target-expressing cells) are not killed.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Anti-idiotype binding to the extracellular scFv of CD19 CAR to trigger CAR signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06045910
disease_id_num_tar_ref
4472
drug_id_num_tar_ref
12083