gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ALETA-001 bridges anti-CD19 CAR T cells to malignant B cells by binding their surface antigens, forming an immune synapse that reactivates CAR T cells and triggers perforin/granzyme-mediated cytotoxic killing of the antigen-expressing tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Specific B-cell antigen targets not detailed in the clinical trial record
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06045910
disease_id_num_tar_ref
4472
drug_id_num_tar_ref
12083