gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-based bispecific bridges CD3 on T cells to the MAGE-A4/HLA-A*02 pHLA on target cells, forming an immune synapse and activating cytotoxic T cells to kill via perforin/granzyme (and Fas–FasL)–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*02-restricted peptide–HLA (pMHC) complex; commonly HLA-A*02:01
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06372574
disease_id_num_tar_ref
4483
drug_id_num_tar_ref
12108