gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This ADC binds TROP2 (not Topoisomerase I), is internalized, and releases a payload that inhibits topoisomerase I to induce DNA damage. Cells are killed due to TROP2-directed delivery, not because they express Topoisomerase I.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload target; enzyme inhibition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06422143
disease_id_num_tar_ref
4546
drug_id_num_tar_ref
12274