gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
LM-302 binds CLDN18.2 on tumor cells, is internalized, and releases MMAE, which inhibits tubulin polymerization to cause G2/M arrest and apoptosis. Tubulin itself is not the antibody target; only CLDN18.2+ cells are directly targeted and killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of MMAE payload; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05994001
disease_id_num_tar_ref
4574
drug_id_num_tar_ref
12366