gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti‑CD38 IgG1 binds CD38 on target cells and triggers Fc‑mediated effector functions—ADCC (NK cells), CDC (complement), and ADCP (phagocytes)—leading to depletion of CD38+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ecto-enzyme (NADase/ADP-ribosyl cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06100237
disease_id_num_tar_ref
4586
drug_id_num_tar_ref
12395