gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccinated dendritic cells prime/expand neoantigen-specific CD8+ T cells, which then recognize the neoantigen peptide–HLA I on tumor cells and kill them via TCR-mediated cytotoxicity (perforin/granzyme, Fas–FasL).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized by CD8+ T-cell TCR; peptide–MHC I restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751940
disease_id_num_tar_ref
412
drug_id_num_tar_ref
1158