gene_symbol
CD2
hgnc_id
HGNC:1639
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD2 antibody binds CD2 on T/NK cells and engages Fc effector functions, causing NK cell–mediated ADCC and complement-dependent cytotoxicity (CDC), with possible apoptosis of CD2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD2–LFA-3 (CD58) co-stimulatory/adhesion interaction; depletes CD2+ lymphocytes via Fc effector functions (ADCC/CDC).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05669001
disease_id_num_tar_ref
4598
drug_id_num_tar_ref
12435