gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD80/CD86 on the infused dendritic cells provide costimulation to prime neoantigen-specific T cells; the resulting T cells kill tumor cells presenting the neoantigen via MHC, not the CD80/CD86-expressing dendritic cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory checkpoint; competes with CD28 for B7 ligands
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751940
disease_id_num_tar_ref
412
drug_id_num_tar_ref
1158