gene_symbol
PDCD1
hgnc_id
HGNC:8760
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PD-1 is knocked out in the CAR T cells to enhance their function; the CAR T cells kill CD19+ targets via immune synapse–mediated perforin/granzyme cytolysis, not PD-1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Gene editing knockout; CAR cassette integrated at PDCD1 locus
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05741359
disease_id_num_tar_ref
4644
drug_id_num_tar_ref
12559