gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binding to EGFR opsonizes target cells and engages Fcγ receptors on effector cells, leading to ADCC by NK cells and ADCP by macrophages, killing EGFR+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; IgG1 Fc can engage Fcγ receptors to mediate ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508606
disease_id_num_tar_ref
4660
drug_id_num_tar_ref
12600