gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on infused TILs (CD4+ T cells) recognize patient-specific neoantigen peptides presented on MHC II (HLA-DR/DQ/DP) and directly kill target cells via perforin/granzyme and Fas–FasL pathways, with IFN-γ supporting cytotoxic activity.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC II complex recognized by CD4+ TIL TCRs; HLA-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06491225
disease_id_num_tar_ref
4699
drug_id_num_tar_ref
12716