gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize tumor-associated peptides on HLA class II via native TCRs; CD4+ T cells directly lyse presenting cells through perforin/granzyme and Fas-FasL, with IFN-γ enhancing cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC II complex recognized by CD4+ TIL TCRs; HLA-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06491225
disease_id_num_tar_ref
4699
drug_id_num_tar_ref
12716