gene_symbol
BIRC5
hgnc_id
HGNC:593
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic-cell vaccination primes survivin-specific CD8+ T cells, which recognize survivin peptide–HLA class I complexes on target cells and kill them via perforin/granzyme-mediated cytotoxicity (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by autologous dendritic cells on MHC class I to activate CD8+ cytotoxic T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06524063
disease_id_num_tar_ref
4708
drug_id_num_tar_ref
12731