gene_symbol
BIRC5
hgnc_id
HGNC:593
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic-cell vaccination primes survivin-specific T cells; activated CD8+ CTLs (and cytotoxic CD4+ T cells when tumor is HLA II+) recognize survivin peptides on tumor cells and kill via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by autologous dendritic cells on MHC class II to activate CD4+ helper T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06524063
disease_id_num_tar_ref
4708
drug_id_num_tar_ref
12731