gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Inhibits anti‑apoptotic BCL‑2 in target cells, freeing pro‑apoptotic factors to activate BAX/BAK, causing mitochondrial outer membrane permeabilization, cytochrome c release, caspase activation, and intrinsic apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-mimetic; binds BH3-binding groove to inhibit anti-apoptotic BCL-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06351527
disease_id_num_tar_ref
4726
drug_id_num_tar_ref
12779