gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocking the CD47–SIRPα checkpoint removes the don’t-eat-me signal, enabling macrophage FcγR-mediated antibody-dependent cellular phagocytosis of CD47-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks the CD47–SIRPα interaction ('don't-eat-me' signal)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06196203
disease_id_num_tar_ref
4830
drug_id_num_tar_ref
13041