gene_symbol
CSF1R
hgnc_id
HGNC:2433
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Emactuzumab (IgG1) binds CSF1R on target cells and engages Fcγ receptor–bearing effector cells to induce ADCC/ADCP (and potentially CDC), depleting CSF1R+ macrophages/giant cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor tyrosine kinase; antibody binds extracellular domain to block CSF1/IL34 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05417789
disease_id_num_tar_ref
4902
drug_id_num_tar_ref
13217