gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, is internalized, and releases MMAE, which binds beta-tubulin to disrupt microtubules and induce G2/M arrest and apoptosis; beta-tubulin is not the antigen recognized by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-binding site engaged by MMAE payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05898373
disease_id_num_tar_ref
4934
drug_id_num_tar_ref
13294