gene_symbol
KIT
hgnc_id
HGNC:6342
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks SCF–c-Kit survival signaling on CD117+ hematopoietic stem cells, leading to loss of pro‑survival signals and apoptosis/depletion rather than direct immune cell–mediated killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks stem cell factor (SCF/KITLG) binding to KIT
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05907746
disease_id_num_tar_ref
4951
drug_id_num_tar_ref
13349