gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Eribulin binds the vinca domain of beta‑tubulin, blocking microtubule polymerization and causing G2/M arrest and apoptosis (after intracellular delivery/release).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Eribulin binds the vinca site on β-tubulin at microtubule plus ends to inhibit polymerization; interacts with multiple β-tubulin isotypes.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05613088
disease_id_num_tar_ref
4966
drug_id_num_tar_ref
13386