gene_symbol
LGR5
hgnc_id
HGNC:4504
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages immune effectors (e.g., NK cells) to mediate ADCC against tumor cells when the bispecific binds LGR5 (preferentially on EGFR+/LGR5+ cells), leading to targeted lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06496178
disease_id_num_tar_ref
4999
drug_id_num_tar_ref
13493