gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2, is internalized, and releases the DM1 payload inside the cell to disrupt microtubules, causing mitotic arrest and apoptosis; Fc can also mediate ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds HER2 extracellular domain (subdomain IV)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06718335
disease_id_num_tar_ref
5034
drug_id_num_tar_ref
13611