gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8 T cells, which kill tumor cells only if they present the neoantigen peptide in MHC I (e.g., HLA-C) via perforin/granzyme or Fas–FasL; HLA-C itself is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presents neoantigen peptides to CD8+ T cells
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751849
disease_id_num_tar_ref
5036
drug_id_num_tar_ref
13616