gene_symbol
HLA-DRB1
hgnc_id
HGNC:4948
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine presents neoantigen peptides via MHC I/II to prime tumor-specific T cells; cytotoxic CD8 T cells then kill tumor cells displaying the neoantigens on MHC I. HLA-DRB1 (MHC II)–expressing cells are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presents neoantigen peptides to CD4+ T cells
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751849
disease_id_num_tar_ref
5036
drug_id_num_tar_ref
13616