gene_symbol
HLA-DQA1
hgnc_id
HGNC:4942
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes neoantigen-specific T cells, which kill tumor cells presenting those neoantigen peptides (mainly via MHC I) by perforin/granzyme or Fas–FasL. HLA-DQA1 expression itself is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Forms HLA-DQ with HLA-DQB1 to present peptides to CD4+ T cells
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751849
disease_id_num_tar_ref
5036
drug_id_num_tar_ref
13616