gene_symbol
TPBG
hgnc_id
HGNC:12004
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti-5T4 antibody-drug conjugate binds 5T4 on target cells, is internalized, and releases MMAE, which inhibits tubulin polymerization causing G2/M arrest and apoptosis of 5T4-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface oncofetal antigen targeted by the antibody component of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06545331
disease_id_num_tar_ref
5083
drug_id_num_tar_ref
13738