gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
XB010 targets 5T4 on the cell surface; after 5T4-mediated internalization, its MMAE payload binds beta-tubulin to disrupt microtubules. Beta-tubulin expression alone does not trigger targeting or killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06545331
disease_id_num_tar_ref
5083
drug_id_num_tar_ref
13738