gene_symbol
MUC16
hgnc_id
HGNC:15582
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-MUC16 CAR T cells recognize MUC16 on target cells, activate, and directly lyse them via T-cell cytotoxic pathways (perforin/granzyme release and Fas-FasL-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface extracellular domain on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06469281
disease_id_num_tar_ref
5096
drug_id_num_tar_ref
13778