gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IKS03 binds CD19 on B cells, is internalized, and releases a PBD payload that crosslinks DNA in the minor groove, blocking replication/transcription and inducing apoptosis of CD19+ cells; DNA minor-groove binding is not the targeted antigen for cell selectivity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
PBD payload binds and crosslinks DNA to block replication/transcription
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05365659
disease_id_num_tar_ref
5105
drug_id_num_tar_ref
13820