gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Blocking CD47–SIRPα removes the ‘don’t‑eat‑me’ signal and, via the IgG4 Fc engaging Fcγ receptors, directly promotes macrophage/monocyte antibody‑dependent cellular phagocytosis of CD47+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Innate immune checkpoint ligand ('don't-eat-me' signal)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05507541
disease_id_num_tar_ref
5257
drug_id_num_tar_ref
14293