gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Blocks the CD47–SIRPα “don’t‑eat‑me” signal and engages Fcγ receptors, enabling macrophage/monocyte antibody‑dependent cellular phagocytosis of CD47+ cells, leading to their killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD47–SIRPα checkpoint via SIRPα domain of fusion protein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05507541
disease_id_num_tar_ref
5257
drug_id_num_tar_ref
14295