gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TTI-621 binds CD47 on tumor cells; its Fc engages FcγRI (CD64) on macrophages/monocytes to activate antibody-dependent cellular phagocytosis of CD47+ targets. CD64+ cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc-mediated engagement on myeloid effector cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05507541
disease_id_num_tar_ref
5257
drug_id_num_tar_ref
14295