gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TTI-621 binds CD47 on tumor cells and, via its IgG1 Fc, engages Fc gamma receptor IIa on macrophages/monocytes to trigger antibody-dependent cellular phagocytosis of CD47+ tumor cells; Fc gamma receptor IIa–expressing cells act as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc-mediated engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05507541
disease_id_num_tar_ref
5257
drug_id_num_tar_ref
14295