gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16A is on effector cells (NK cells/macrophages). TTI-621 binds CD47 on tumor cells and its Fc engages CD16A to activate phagocytosis/ADCC against CD47+ tumor cells; CD16A+ cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc-mediated engagement on NK/macrophages
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05507541
disease_id_num_tar_ref
5257
drug_id_num_tar_ref
14295