gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on target cells, is internalized, and releases a topoisomerase I inhibitor payload that causes DNA damage (leading to apoptosis), directly killing TROP2-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by the monoclonal antibody component of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06170788
disease_id_num_tar_ref
5318
drug_id_num_tar_ref
14472